MCHC optimal range and reference range

Compiled by Alina Radu, founder of Sera, from the published sources below · Last reviewed November 9, 2026

Sera's bands for MCHC:

  • Optimal 33 – 35 g/dL (330 – 350 g/L); sufficient 32 – 36 g/dL (320 – 360 g/L); out of range below 32 or above 36 g/dL.

Evidence grade: Published reference interval. A band that primarily reflects a published adult laboratory or population reference interval. It is not necessarily applicable to every assay or laboratory.

All units

UnitOptimalSufficientOut of range
g/dL33 – 3532 – 36below 32 or above 36
g/L330 – 350320 – 360below 320 or above 360
%33 – 3532 – 36below 32 or above 36

What the evidence says

The acceptable band of 32 to 36 g/dL (320 to 360 g/L) is the standard adult reference interval. Low values go with iron deficiency and thalassaemia; a high value is uncommon and is often a sample artefact (haemolysis, lipaemia, cold agglutinins) or spherocytosis. The optimal band of 33 to 35 g/dL has no published source behind it.

Sources

  • RBC indices — U.S. National Library of Medicine (MedlinePlus Medical Encyclopedia), 2026 · Government / public-health guidanceNormal MCHC is 32 to 36 g/dL, or 320 to 360 g/L (reviewed February 2026). Sera's sufficient band exactly, in both units.
  • CBC blood test — U.S. National Library of Medicine (MedlinePlus Medical Encyclopedia), 2024 · Government / public-health guidanceNormal MCHC is 32 to 36 g/dL.
  • Full Blood Count (Haematology) — Liverpool Clinical Laboratories, Royal Liverpool University Hospital (NHS), 2013 · Laboratory / reference-interval sourceMCHC 320 to 370 g/L. Same lower limit; upper limit 10 g/L above Sera's. The page is undated; it is the laboratory's current page and says these ranges replaced the ones used before 2 April 2013.

What Mean Corpuscular Hemoglobin Concentration (MCHC) measures

The average concentration of hemoglobin inside your red blood cells.

Low MCHC points to a type of anemia usually caused by iron deficiency.

Related blood cell health markers

See MCHC in the full list of biomarker ranges

About the author

Alina Radu is the founder of Sera and a software engineer. The idea started with her own Hashimoto's tests, scattered across years without the big picture. She is not a clinician: these ranges are compiled from the published sources linked on each page, with every source named. Alina Radu on LinkedIn

This page is a reference for practitioners, not medical advice. Sera's bands are practitioner targets for structured review, not diagnostic thresholds, and Sera does not diagnose or recommend treatment. Read a result alongside the interval printed by the issuing laboratory and the client's history and symptoms. Range set: Sera Production, version 1.0, last reviewed November 9, 2026.