Uric Acid optimal range and reference range
Compiled by Alina Radu, founder of Sera, from the published sources below · Last reviewed November 9, 2026
Sera's bands for Uric Acid, which differ for men and women:
- Female: Optimal 3.5 – 5.5 mg/dL (208 – 327 μmol/L); sufficient 2.5 – 6 mg/dL (149 – 357 μmol/L); out of range below 2.5 or above 6 mg/dL.
- Male: Optimal 3.5 – 5.5 mg/dL (208 – 327 μmol/L); sufficient 2.5 – 7 mg/dL (149 – 416 μmol/L); out of range below 2.5 or above 7 mg/dL.
Evidence grade: Established clinical threshold. A band edge that corresponds to a recognised diagnostic, risk or treatment threshold from a major clinical guideline or public-health body.
All units
| Unit | Applies to | Optimal | Sufficient | Out of range |
|---|---|---|---|---|
| mg/dL | Female | 3.5 – 5.5 | 2.5 – 6 | below 2.5 or above 6 |
| mg/dL | Male | 3.5 – 5.5 | 2.5 – 7 | below 2.5 or above 7 |
| μmol/L | Female | 208 – 327 | 149 – 357 | below 149 or above 357 |
| μmol/L | Male | 208 – 327 | 149 – 416 | below 149 or above 416 |
| mmol/L | Female | 0.208 – 0.327 | 0.149 – 0.357 | below 0.149 or above 0.357 |
| mmol/L | Male | 0.208 – 0.327 | 0.149 – 0.416 | below 0.149 or above 0.416 |
What the evidence says
The acceptable band ends where hyperuricaemia is conventionally defined: above 7 mg/dL in men and above 6 in women. Where the client's sex is not recorded, the men's figure is used. The optimal band ending at 5.5 mg/dL is a functional target, supported by cohort data in which cardiovascular deaths rose from 5.6. The lower edges have no published threshold behind them.
Sources
- Hyperuricemia — StatPearls — NCBI Bookshelf, US National Library of Medicine, 2023 · Peer-reviewed publicationDefines hyperuricaemia as a serum uric acid usually greater than 6 mg/dL in women and 7 mg/dL in men. The two ceilings of Sera's acceptable band.
- Identification of the Uric Acid Thresholds Predicting an Increased Total and Cardiovascular Mortality Over 20 Years — Virdis A, Masi S, Casiglia E, et al. — Hypertension, 2020 · Peer-reviewed publicationIn 22,714 Italian adults followed for 20 years, the uric acid level above which deaths rose was 4.7 mg/dL for all causes and 5.6 mg/dL for cardiovascular causes, both well below the level that defines hyperuricaemia. Observational support for an optimal band ending at 5.5.
What Uric Acid measures
A waste product made when the body breaks down substances called purines.
High uric acid is a sign of metabolic problems and raises the risk of gout and heart disease.